Resolution promptly occurred within 24–48 h on discontinuation of concomitant therapy in patients who developed signs and symptoms of serotonin syndrome.When using the Boyer criteria, the onset of serotonin syndrome can be clearly recognized if physicians are familiar with the signs and symptoms (i.e., the presence of myoclonus, inducible clonus, tremor, and hyperreflexia, all of which are not typical of infection or sepsis). Patients were considered to have a low probability of serotonin syndrome if they met at least 3 Sternbach clinical criteria or any of the Boyer criteria for serotonin syndrome and if their symptoms did not progress with continued therapy or if concomitant therapy was stopped but symptoms did not resolve.
Sixty-four of these patients did not meet at 3 of the Sternbach clinical criteria or any of the Boyer criteria for diagnosis of serotonin syndrome. Adult & adolescent ≥12 yr Nosocomial & community-acquired pneumonia, complicated skin & skin structure infections 600 mg IV or PO every 12 hr for 10-14 days.Vancomycin-resistant Enterococcus faecium infections 600 mg IV or PO every 12 hr for 14-28 days.Uncomplicated skin & skin structure infections Adult 400 mg PO every 12 hr for 10-14 days. A dangerous drug interaction could occur. Patients were categorized as having or not having a documented diagnosis of serotonin syndrome. ZYVOX ® Drug Interactions (linezolid) 7 DRUG INTERACTIONS 7.1 Monoamine Oxidase Inhibitors Linezolid is a reversible, nonselective inhibitor of monoamine oxidase.
Check with your Linezolid has severe interactions with at least 48 different drugs.Linezolid has serious interactions with at least 112 different drugs. These include increased formation of serotonin, increased release of serotonin, inhibition of serotonin metabolism, decreased reuptake of serotonin, direct serotonin receptor agonism, and increased postsynaptic response. Zyvox Drug Interactions If you are taking Zyvox, be aware that this antibiotic can cause serious reactions with many other medications, such as Prozac, albuterol, methadone, and dopamine.
However, only 2 (3%) of these patients had high-probability cases, whereas the other 2 (3%) had low-probability cases. Drug interactions are reported among people who take Zyvox and Prozac together.
The study is created by eHealthMe based on reports of 88 people who take Zyvox and Prozac from the Food and Drug Administration (FDA), and is updated regularly. Both patients were receiving at least 1 other serotonergic agent, which may increase the potential for signs and symptoms of serotonin syndrome.Limitations of this study include its retrospective nature. All generic drug interactions for linezolid oral (lists will include brand and generic names): 84 contraindicated drug interactions 198 serious drug interactions This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.
This patient did not receive any other serotonergic medications. Manage your drugs with real-world data: Clinical trials are run among a selected group of people. Wait at least 14 days after discontinuing citalopram before initiating therapy with linezolid” [Serotonin syndrome is a progressive syndrome consisting of a clinical triad of symptoms, including mental status changes, autonomic hyperactivity, and neuromuscular abnormalities. It should be noted, however, that both patients with high probability of serotonin syndrome were receiving concomitant therapy with linezolid and an SSRI. Any combination of these mechanisms may potentially increase the risk for serotonin syndrome. Diagnosis is made on the basis of clinical manifestations and a history of drug exposure to a known medication with serotonergic properties, in temporal relationship with the clinical features. New Orleans, Louisiana This information does not contain all possible interactions or adverse effects.
Seven patients did not receive both types of therapy within a 14-day period and were excluded from the study.